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Zobone (Zoledronic Acid) ::Cancer Medicine



4mg (1 Vial)
MRP Our Price
Rs. 3017.00 Rs. 2413.60
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Brand Name – Zobone

Generic Name - Zoledronic Acid
Why would this drug be used?
Zoledronic acid is a type of drug known as a bisphosphonate. It is used to help treat cancer that has spread to the bones, usually along with other treatments such as chemotherapy. It lowers the risk of fractures and other bone problems. It is also used to lower high blood calcium levels in people who have cancer in the bones.
How does this drug work?
Some cancers that start in the bones (such as multiple myeloma) or that can spread to the bones (such as breast cancer) can cause the breakdown of bone. This process can release large amounts of calcium into the blood. This condition, known as hypercalcemia, can be dangerous. Cancer in the bones can also lead to fractures and other problems.
Zoledronic acid stops bone cells called osteoclasts from breaking down the hard mineral structure of bone. This slows the growth of tumors in the bone. It also slows the release of calcium into the blood, which helps lower calcium levels in the body.
Before taking this medicine Tell your doctor…
If you are allergic to anything, including medicines, dyes, additives, or foods.
If you have ever had kidney disease. This drug may affect the kidneys, and should be used with extreme caution in people with serious kidney problems.
If you have any mouth or teeth problems, or if you plan to have dental work in the near future. This drug has been linked to serious damage of the jawbone in some people, especially if they have had recent dental work (see “Precautions” below).
If you have any other medical conditions such as liver disease (including hepatitis), heart disease, congestive heart failure, lung disease, diabetes, gout, or infections. You may need closer monitoring of these conditions while being treated.
If you are pregnant, trying to get pregnant, or if there is any chance of pregnancy. This drug may cause problems if either the male or female is taking it at the time of conception or during pregnancy. Check with your doctor about what kinds of birth control can be used with this medicine. This drug should not be used during pregnancy.
If you are breast-feeding. Although information about this drug is not available, many drugs pass into breast milk and may affect the baby. Talk with your doctor about the possible risks of breast-feeding while taking this drug.
If you think you might want to have children in the future. It is not known whether or not this drug can affect fertility. Talk with your doctor about the possible risk with this drug and the options that may preserve your ability to have children.
About any other prescription or over-the-counter medicines you are taking, including vitamins and herbs. In fact, keeping a written list of each of these medicines (including the doses of each and when you take them) with you in case of emergency may help prevent complications if you get sick.
How is this drug taken or given?
Zoledronic acid is given as an injection into a vein (intravenous, or IV) over 15 minutes or more. The usual dose is 4 milligrams (mg), although the dose may need to be lower in people with kidney problems. The timing will depend on the reason you are getting the drug. When zoledronic acid is used to treat high blood calcium levels it is often given as a one-time dose. To help treat tumors in the bones, it is often given once every 3 to 4 weeks.
You will likely be given IV fluids and/or advised to drink plenty of fluids while getting this drug to keep you hydrated and reduce the chance of kidney damage. Your doctor may also recommend that you take a multi-vitamin (with vitamin D) and a calcium supplement each day.
Your doctor may delay or even stop this drug if your kidney function tests are abnormal (see “Precautions”).
Within the first few days of getting this drug, some people have a flu-like illness with chills, fever, and tiredness, with bone and muscle pain. These symptoms usually go away on their own within a week or two.
A few people have breathing problems such as cough, tightness in the throat, or wheezing when getting this drug. Some have other kinds of breathing problems, such as shortness of breath or tightness in the chest. Tell your doctor right away if any of this happens to you; it can happen again the next time you get the drug.
This drug may affect your kidney function. Your doctor will do blood tests to watch your kidneys closely while you’re being treated. You may need to delay or stop treatment if these tests become abnormal. Your doctor may also recommend that you get plenty of fluids while getting this drug to reduce the chance of kidney damage. Tell your doctor or nurse right away if you notice blood in the urine, lowered urine output, increased thirst, nausea, or vomiting.
In rare cases, this drug can damage the bones in the jaw, a condition called osteonecrosis of the jaw (ONJ). Most cases have been in people who had recent dental procedures such as having a tooth pulled while taking the drug. Your doctor may recommend that you get a thorough dental exam before you start taking this drug. Talk with your dentist about the best ways to prevent problems while on this drug. While you are getting treatment, check with your doctor before having any dental work done. Tell your doctor if you notice loose teeth, swollen gums, or pain or numbness in your jaw.
In rare cases, taking this drug could lead to low blood calcium levels (hypocalcemia). Possible symptoms could include muscle spasms or cramps, muscle or joint pains, changes in sensations on the face, hands or feet, confusion, or seizures. Tell your doctor right away if you notice any of these symptoms.
Your doctor will test your blood often during your treatment, looking for possible effects of the drug on the kidneys and blood chemistry levels. Based on the test results, your doctor may need to change your treatment plan. Be sure to keep all your appointments for lab tests and doctor visits.
In rare cases, this drug may cause allergic reactions when the drug is given. Mild reactions may consist of hives or fever and chills. More serious reactions happen rarely, but can be dangerous. Symptoms can include feeling lightheaded or dizzy (due to low blood pressure), fever or chills, hives, nausea, itching, headache, coughing, shortness of breath, or swelling of the face, tongue, or throat. Tell your doctor or nurse right away if you notice any of these symptoms during or after being given the drug.
Avoid pregnancy while taking this drug and for some time afterward. The drug can harm the fetus and may cause problems for the mother during delivery. The drug can stay in your body for years after you stop taking it, and may affect fetal bone formation. Talk with your doctor about this.
Possible side effects
You will probably not have most of the following side effects, but if you have any, talk to your doctor or nurse. They can help you understand the side effects and cope with them.
Fever (lasting a few days after the infusion)*
Flu-like symptoms (fever, chills, flushing, bone and muscle aches) in the first 3 days after your injection, which may last a week or more*
Pain or redness at injection site
Less common
Bone or joint pain
Muscle aches
Runny nose
Loss of appetite
Shortness of breath
Feeling dizzy or faint
Feeling tired
Urinary tract infection
Anemia (low red blood cell counts) which can cause tiredness, shortness of breath
Blood test results showing the drug may be affecting your kidneys (Your doctor will explain the importance of these findings, if any.)*
Trouble sleeping
Low blood calcium levels (could lead to muscle pain, cramps, or spasms; abnormal sensations on the face, hands, or feet; or seizures)*
Damage to bones in jaw*
Broken femur (thigh bone) after little or no injury, starting with groin or thigh pain
Serious allergic reactions*
Kidney failure
Trouble breathing, coughing, tightness in the chest*
Irregular heartbeat (atrial fibrillation)
Bone and/or joint pain severe enough to require the drug be stopped
Eye irritation or redness
Disclaimer: The information provided above is general. It does not include all possible uses, actions, precautions, side effects, or interactions. It is not intended as medical advice, and should not be relied upon as a substitute for your doctor’s advice. Please consult your doctor before taking any action towards your medical condition.

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